EN 生科百年 内网 新内网

检测到您当前使用浏览器版本过于老旧,会导致无法正常浏览网站;请您使用电脑里的其他浏览器如:360、QQ、搜狗浏览器的极速模式浏览,或者使用谷歌、火狐等浏览器。

下载Firefox
王伟

邮  箱: oneway1985 (AT) pku.edu.cn

职  称:研究员

办公室电话:62753015

办公室地址:北京市海淀区颐和园路5号,威人斯尼平台注册,金光生命科学大楼,100871

所属实验室:王伟实验室

实验室电话:62753015

实验室地址:北京市海淀区颐和园路5号,威人斯尼平台注册,金光生命科学大楼,100871

个人主页:http://www.researchgate.net/profile/Wei_Wang91

  • 个人简介
  • 科研领域
  • 代表性论文

教育经历:

2007 - 2012,博士,生物学,杜克大学
2003 - 2007,学士,生物技术,复旦大学

工作经历:

2018 - 至今,研究员,威人斯尼平台注册,生命科学联合中心
2014 - 2018,助理教授,爱荷华州立大学
2013 - 2014,博士后,杜克大学

执教课程:

本科生课程:网络科学和系统生物学基础,01132683,每年秋季学期
研究生课程:文献和生物网络构建与分析,01108171,每年秋季学期
研究生课程:现代生物学基础(一),08406002,每年秋季学期
研究生课程:生命科学实验基础,08409018,每年秋季学期
          在基础研究方面,主要致力于阐明植物中应激颗粒的形成机制、生物学功能和进化学意义。应激颗粒是一种重要的转录后和翻译调控方式。对哺乳动物细胞的研究表明,应激颗粒与神经退行性疾病、肿瘤凋亡、病毒侵染、免疫、炎症反应等密切相关。然而,应激颗粒在植物中的功能有待解析。本实验室综合运用细胞生物学、分子生物学、蛋白质组学、基因组学和生物信息学等手段发现了植物诱导应激颗粒形成的分子学机制、解析了植物应激颗粒的蛋白组分并对其生物学功能进行了探索。
    在作物研究方面,主要关注大豆根系生物钟与大豆孢囊线虫互作的分子机理。近年来对于植物生物钟的深入研究确立了其在拮抗叶片病原体中的关键作用。而对于植物生物钟和根系病原体之间的互作知之甚少。因此解析植物根系生物钟与孢囊线虫之间的互作及相关信号转导途径将填补这一重要的空白。孢囊线虫是目前限制大豆产量最主要的病虫害。每年在全球造成数十亿美元的经济损失。对于孢囊线虫与大豆根系生物钟互作机理的理解将有助于发现拮抗孢囊线虫新的生物靶标。
1 Fu, M., Zhou, Y., Zhang, X., Yang, K., Xu, Y., Wang, X., Chen, Z., Wang, Y., Shi, Y., Ma, L., Liu, H., Deng, Y., Cheng, S., Chu, J., Song, J., Sun, T., Wang, Y., Wang, W. & Zhou, M. A pathogen effector HaRxL10 hijacks the circadian clock component CHE to perturb both plant development and immunity. Nature Communications 16, 1538 (2025).
2 Xie, Z., Zhao, S., Tu, Y., Liu, E., Li, Y., Wang, X., Chen, C., Zhai, S., Qi, J., Wu, C., Wu, H., Zhou, M. & Wang, W.* Proteasome resides in and dismantles plant heat stress granules constitutively. Molecular Cell 84, 3320-3335 (2024). (*corresponding author)
3 Wu, C., Wang, X., Li, Y., Zhen, W., Wang, C., Wang, X., Xie, Z., Xu, X., Guo, S., Botella, J.R., Zheng, B., Wang, W., Song, C.-P. & Hu, Z. Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance. Nature Communications 15, 7696 (2024).
4 Xie, Z., Zhao, S., Li, Y., Deng, Y., Shi, Y., Chen, X., Li, Y., Li, H., Chen, C., Wang, X., Liu, E., Tu, Y., Shi, P., Tong, J., Gutierrez-Beltran, E., Li, J., Bozhkov, P.V., Qian, W., Zhou, M.* & Wang, W.* Phenolic acid-induced phase separation and translation inhibition mediate plant interspecific competition. Nature Plants 9, 1481-1499 (2023). (*corresponding author)
5 Wang, X., Hu, Y. & Wang, W.* Comparative Analysis of Circadian Transcriptomes Reveals Circadian Characteristics between Arabidopsis and Soybean. Plants 12, 3344 (2023). (*corresponding author)
6 Feng, S., Yu, Y., Ma, J., Wang, X., Song, X., Xu, H., Li, Y., Mo, K., Liu, P., Song, X., Xie, Z., Wang, Y.*, Su, X.-d.*, Wang, W.* & Chen, C.* High-affinity aptamers enable the rapid optical detection and differentiation of three SARS-CoV-2 VOCs. Microchemical Journal 195, 109508 (2023). (*corresponding author)
7 Chen, C., Song, X., Yu, Y., Wang, X., Xu, H., Ji, W., Ma, J., Zhao, C., Feng, S.*, Wang, Y.*, Su, X.-d.* & Wang, W.* Aptamer-based nanointerferometer enables amplification-free ultrasensitive detection and differentiation of SARS-CoV-2 variants. Analytica Chimica Acta 1260, 341207 (2023). (*corresponding author)
8 Zhou, M. & Wang, W.* SOS1 safeguards plant circadian rhythm against daily salt fluctuations. Proceedings of the National Academy of Sciences 119, e2212950119 (2022). (*corresponding author)
9 Wang, W.* & Gu, Y.* The emerging role of biomolecular condensates in plant immunity. Plant Cell 34, 1568-1572 (2022). (*corresponding author)
10 Tong, J., Ren, Z., Sun, L., Zhou, S., Yuan, W., Hui, Y., Ci, D., Wang, W., Fan, L.-M., Wu, Z. & Qian, W. ALBA proteins confer thermotolerance through stabilizing HSF messenger RNAs in cytoplasmic granules. Nature Plants 8, 778-791 (2022).
11 Wang, X., Xu, Y., Zhou, M.* & Wang, W.* in Modeling Transcriptional Regulation: Methods and Protocols (ed Shahid Mukhtar) 215-225 (Springer US, 2021). (*corresponding author)
12 Feng, S., Chen, C., Song, C., Ding, X., Wang, W. & Que, L. Optical Aptamer-Based Sensors for Detecting Plant Hormones. IEEE Sensors Journal 21, 5743-5750 (2021).
13 Li, M., Cao, L., Mwimba, M., Zhou, Y., Li, L., Zhou, M., Schnable, P. S., O`Rourke, J. A., Dong, X.* & Wang, W.* Comprehensive mapping of abiotic stress inputs into the soybean circadian clock. Proceedings of the National Academy of Sciences of the United States of America 116, 23840-23849 (2019). (*corresponding author)
14 Chen, C., Feng, S., Zhou, M., Ji, C., Que, L.* & Wang, W.* Development of a structure-switching aptamer-based nanosensor for salicylic acid detection. Biosensors and Bioelectronics 140, 111342 (2019). (*corresponding author)
15 Zhou, M. & Wang, W.* Recent Advances in Synthetic Chemical Inducers of Plant Immunity. Front Plant Sci 9, 1613 (2018). (*corresponding author)
16 Feng, S., Chen, C., Wang, W.* & Que, L.* An aptamer nanopore-enabled microsensor for detection of theophylline. Biosensors and Bioelectronics 105, 36-41 (2018). (*corresponding author)
17 Song, C., Chen, C., Che, X., Wang, W. & Que, L. (2017). Detection of plant hormone abscisic acid (ABA) using an optical aptamer-based sensor with a microfluidics capillary interface. 22-26 Jan. 2017. pp. 370-373.
18 Feng, S., Che, X., Que, L.*, Chen, C. & Wang, W.* (2016). Rapid detection of theophylline using aptamer-based nanopore thin film sensor. 30 Oct.-3 Nov. 2016. pp. 1-3. (*corresponding author)
19 Zhou, M.*, Wang, W.*, Karapetyan, S., Mwimba, M., Marqués, J., Buchler, N. E. & Dong, X. Redox rhythm reinforces the circadian clock to gate immune response. Nature 523, 472-476 (2015). (*co-first author)
20 Wang, S., Gu, Y., Zebell, Sophia G., Anderson, Lisa K., Wang, W., Mohan, R. & Dong, X. A Noncanonical Role for the CKI-RB-E2F Cell-Cycle Signaling Pathway in Plant Effector-Triggered Immunity. Cell Host & Microbe 16, 787-794 (2014).
21 Yan, S., Wang, W., Marqués, J., Mohan, R., Saleh, A., Durrant, Wendy E., Song, J. & Dong, X. Salicylic Acid Activates DNA Damage Responses to Potentiate Plant Immunity. Molecular Cell 52, 602-610 (2013).
22 Pajerowska-Mukhtar, Karolina M., Wang, W., Tada, Y., Oka, N., Tucker, Chandra L., Fonseca, Jose P. & Dong, X. The HSF-like Transcription Factor TBF1 Is a Major Molecular Switch for Plant Growth-to-Defense Transition. Current Biology 22, 103-112 (2012).
23 Fu, Z. Q.*, Yan, S.*, Saleh, A.*, Wang, W., Ruble, J., Oka, N., Mohan, R., Spoel, S. H., Tada, Y., Zheng, N. & Dong, X. NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. Nature 486, 228-232 (2012). (*co-first author)
24 Wang, W.*, Barnaby, J. Y.*, Tada, Y., Li, H., Tör, M., Caldelari, D., Lee, D.-u., Fu, X.-D. & Dong, X. Timing of plant immune responses by a central circadian regulator. Nature 470, 110-114 (2011). (*co-first author)

检测到您当前使用浏览器版本过于老旧,会导致无法正常浏览网站;请您使用电脑里的其他浏览器如:360、QQ、搜狗浏览器的极速模式浏览,或者使用谷歌、火狐等浏览器。

下载Firefox